High n-3 fatty acids counteract hyperglycemia-induced insulin resistance in fat-1 mice via pre-adipocyte NLRP3 inflammasome inhibition-Reference-Cited by-同舟云学术

High n-3 fatty acids counteract hyperglycemia-induced insulin resistance in fat-1 mice via pre-adipocyte NLRP3 inflammasome inhibition

Published:2021 Issue:1 Volume:12 Page:230-240
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Yu Qingyao¹²³⁴,Wang Tiantian¹²³⁴,Wang Feng⁵⁶³⁴,Yang Yong⁷⁸³⁴,He Canxia⁹¹⁰²³⁴^ORCID,Yang Wenge¹²³⁴,Zhang JinJie¹²³⁴,Zou Zuquan⁹¹⁰²³⁴^ORCID

Affiliation:

1. College of Food and Pharmaceutical Sciences

2. Ningbo University

3. Ningbo

4. China

5. Department of Laboratory Medicine

6. Ningbo Medical Center Lihuili Hospital

7. Department of Clinical laboratory

8. the affiliated Hospital of Ningbo University

9. Zhejiang Key Laboratory of Pathophysiology

10. Medical School

Abstract

Hyperglycemia induces TXNIP expression and triggers NLRP3 inflammasome-dependent IL-1β secretion, which is counteracted by n-3 PUFAs such as DHA through the PI3K/Akt pathway-mediated downregulation of TXNIP in adipose pre-adipocytes.

Funder

National Key Research and Development Program of China

Ningbo University

Zhejiang Key Laboratory of Pathophysiology

Natural Science Foundation of Zhejiang Province

Natural Science Foundation of Ningbo

Medical Science and Technology Project of Zhejiang Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/FO/D0FO02092C

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