Elucidation of salicylate attachment in celesticetin biosynthesis opens the door to create a library of more efficient hybrid lincosamide antibiotics
Author:
Affiliation:
1. Institute of Microbiology
2. Czech Academy of Sciences
3. BIOCEV
4. 252 50 Vestec
5. Czech Republic
Abstract
Combinatorial biosynthesis for more efficient antibiotics: 150 novel lincosamides prepared by combining lincomycin and celesticetin biosynthetic pathways.
Funder
Ministry of Education, Youth and Sports
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/SC/C6SC04235J
Reference29 articles.
1. B. J. Magerlein , Modification of lincomycin, in Structure-activity relationships among the semisynthetic antibiotics, ed. D. Pearlman, Academic press, New York, 1977, p. 601
2. Clindamycin plus quinine for treating uncomplicated falciparum malaria: a systematic review and meta-analysis
3. Biochemical characterization of l-DOPA 2,3-dioxygenase, a single-domain type I extradiol dioxygenase from lincomycin biosynthesis
4. Lincomycin Biosynthesis Involves a Tyrosine Hydroxylating Heme Protein of an Unusual Enzyme Family
5. Characterization ofN-Demethyllincosamide Methyltransferases LmbJ and CcbJ
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