Lincosamide Antibiotics: Structure, Activity, and Biosynthesis-Reference-Cited by-同舟云学术

Lincosamide Antibiotics: Structure, Activity, and Biosynthesis

Published:2024-01-15 Issue: Volume: Page:
ISSN:1439-4227
Container-title:ChemBioChem
language:en
Short-container-title:ChemBioChem

Author:

Mori Takahiro¹²³^ORCID,Abe Ikuro¹²^ORCID

Affiliation:

1. Graduate School of Pharmaceutical Sciences The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-0033 Japan

2. Collaborative Research Institute for Innovative Microbiology The University of Tokyo 1-1-1 Yayoi, Bunkyo-ku Tokyo 113-8657 Japan

3. PRESTO Japan Science and Technology Agency 4-1-8, Honcho, Kawaguchi Saitama 332-0012 Japan

Abstract

AbstractLincosamides are naturally occurring antibiotics isolated from Streptomyces sp. Currently, lincomycin A and its semisynthetic analogue clindamycin are used as clinical drugs. Due to their unique structures and remarkable biological activities, derivatizations of lincosamides via semi‐synthesis and biosynthetic studies have been reported. This review summarizes the structures and biological activities of lincosamides, and the recent studies of lincosamide biosynthetic enzymes.

Funder

Ministry of Education, Culture, Sports, Science and Technology

New Energy and Industrial Technology Development Organization

Japan Science and Technology Agency

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

Link

https://chemistry-europe.onlinelibrary.wiley.com/doi/am-pdf/10.1002/cbic.202300840

Reference92 articles.

2. Discovery and resupply of pharmacologically active plant-derived natural products: A review

3. The re-emergence of natural products for drug discovery in the genomics era

4. Natural products in drug discovery: advances and opportunities