Discovery of potential antifungal triazoles: design, synthesis, biological evaluation, and preliminary antifungal mechanism exploration-Reference-Cited by-同舟云学术

Discovery of potential antifungal triazoles: design, synthesis, biological evaluation, and preliminary antifungal mechanism exploration

Published:2017 Issue:8 Volume:8 Page:1631-1639
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Zhang Yuan¹²³⁴⁵,Damu Guri L. V.¹²³⁴⁵,Cui Sheng-Feng¹²³⁴⁵,Mi Jia-Li⁶⁷⁸,Tangadanchu Vijai Kumar Reddy¹²³⁴⁵,Zhou Cheng-He¹²³⁴⁵^ORCID

Affiliation:

1. Institute of Bioorganic & Medicinal Chemistry

2. Key Laboratory of Applied Chemistry of Chongqing Municipality

3. School of Chemistry and Chemical Engineering

4. Southwest University

5. Chongqing 400715

6. People's Hospital of Suining

7. Sichuan 629000

8. PR China

Abstract

Synthesis of novel triazole-type miconazole analogues as potential antifungal agents and molecular modeling with CYP51 and experimental investigation with DNA suggested the possible antimicrobial mechanism.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C7MD00112F

Reference57 articles.

1. Antibiotic tolerance facilitates the evolution of resistance

2. Antibacterial drug discovery in the resistance era

3. Comprehensive Review in Current Developments of Imidazole-Based Medicinal Chemistry

4. Azide-enolate 1,3-dipolar cycloaddition in the synthesis of novel triazole-based miconazole analogues as promising antifungal agents

5. New Progress in Azole Compounds as Antimicrobial Agents

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