Charged group surface accessibility determines micelleplexes formation and cellular interaction-Reference-Cited by-同舟云学术

Charged group surface accessibility determines micelleplexes formation and cellular interaction

Published:2015 Issue:17 Volume:7 Page:7559-7564
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Zhang Yu¹²³,Liu Yang⁴²³,Sen Soumyo⁵²³,Král Petr⁵²³⁶²,Gemeinhart Richard A.¹²³⁷²

Affiliation:

1. Department of Biopharmaceutical Sciences

2. University of Illinois

3. Chicago, USA

4. Department of Medicinal Chemistry and Pharmacognosy

5. Department of Chemistry

6. Department of Physics

7. Department of Bioengineering

Abstract

In this article, we investigated charged group presentation on the micelle surfaces and their interaction with miRNA using thermodynamics, biochemistry, and molecular dynamics simulation. Charged group accessibility on cationic micelle surfaces was shown as a mechanism to alter micelleplex formation and stability.

Funder

NIH Office of the Director

National Center for Research Resources

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2015/NR/C5NR00095E

Reference41 articles.

1. Progress in microRNA delivery

2. Influence of Nano-Carrier Architecture on in Vitro siRNA Delivery Performance and in Vivo Biodistribution: Polyplexes vs Micelleplexes