Tetrazolone as an acid bioisostere: application to marketed drugs containing a carboxylic acid
Author:
Affiliation:
1. Rigel Pharmaceuticals
2. Inc.
3. South San Francisco
4. USA
Abstract
Matched molecular pair analysis was used to evaluate the ability of a tetrazolone group to act as a bioisostere of a carboxylic acid.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01646D
Reference29 articles.
1. Properties of Known Drugs. 2. Side Chains
2. Carboxylic Acid (Bio)Isosteres in Drug Design
3. Structure Property Relationships of Carboxylic Acid Isosteres
4. Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design
Cited by 16 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. (Bio)isosteres of ortho- and meta-substituted benzenes;Beilstein Journal of Organic Chemistry;2024-04-19
2. Rapid modular synthesis of indole ethers via dehydrogenative cross-coupling reaction of indoles and alcohols;Organic Chemistry Frontiers;2024
3. Tuning the Reactivity of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators for Optimal in Vivo Efficacy;ACS Medicinal Chemistry Letters;2023-11-21
4. Discovery of 12 (BMS-986172) as a Highly Potent MGAT2 Inhibitor that Achieved Targeted Efficacious Exposures at a Low Human Dose for the Treatment of Metabolic Disorders;Journal of Medicinal Chemistry;2023-09-19
5. Thietanes and Derivatives thereof in Medicinal Chemistry;Current Topics in Medicinal Chemistry;2022-06
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3