Discovery of <b>12</b> (BMS-986172) as a Highly Potent MGAT2 Inhibitor that Achieved Targeted Efficacious Exposures at a Low Human Dose for the Treatment of Metabolic Disorders-Reference-Cited by-同舟云学术

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Discovery of 12 (BMS-986172) as a Highly Potent MGAT2 Inhibitor that Achieved Targeted Efficacious Exposures at a Low Human Dose for the Treatment of Metabolic Disorders

Published:2023-09-19 Issue:18 Volume:66 Page:13135-13147
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Meng Wei^ORCID,Brigance Robert,Mignone James,Negash Lidet,Zhao Guohua,Ahmad Saleem,Wang Wei,Moore Fang,Ye Xiang-Yang,Sun Jung-Hui,Mathur Arvind,Li Yi-Xin,Azzara Anthony,Ma Zhengping,Chu Ching-Hsuen,Cullen Mary Jane,Rooney Suzanne,Harvey Susan,Kopcho Lisa,Abell Lynn,O’Malley Kevin,Keim William,Dierks Elizabeth A.,Chang Shu,Foster Kimberly A.,Harden David,Dabros Marta,Goti Vineet,De Oliveira Claudia,Krishna Gopal,Pelleymounter Mary Ann,Whaley Jean,Robl Jeffrey A.,Cheng Dong,Devasthale Pratik^ORCID

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01147

Reference24 articles.

1. Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism

2. Regulation of Plasma Triglycerides in Insulin Resistance and Diabetes

3. Changes in Triglyceride Levels Over Time and Risk of Type 2 Diabetes in Young Men

4. Current Concepts and Management Approaches in Nonalcoholic Fatty Liver Disease

5. Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase

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