Investigating histidinylated highly branched poly(lysine) for siRNA delivery-Reference-Cited by-同舟云学术

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Investigating histidinylated highly branched poly(lysine) for siRNA delivery

Published:2022 Issue:2 Volume:10 Page:236-246
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Alazzo Ali¹²,Gumus Nurcan²,Gurnani Pratik²^ORCID,Stolnik Snjezana²,Rahman Ruman³^ORCID,Spriggs Keith²,Alexander Cameron²^ORCID

Affiliation:

1. Department of Pharmaceutics, College of Pharmacy, University of Mosul, Mosul, Iraq

2. Division of Molecular Therapeutics and Formulation, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK

3. BioDiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK

Abstract

Here we examined how histidinylation of branched poly-l-lysine impacts delivery efficiency and toxicity of siRNA delivery in glioblastoma cells.

Funder

Engineering and Physical Sciences Research Council

Royal Society

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2022/TB/D1TB01793D

Reference51 articles.

1. Delivery materials for siRNA therapeutics

2. Preclinical and clinical development of siRNA-based therapeutics

3. Pharmacokinetics and biodistribution of recently-developed siRNA nanomedicines

4.

Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach

5. Efficient nanocarriers of siRNA therapeutics for cancer treatment

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