Charge neutralized poly(β-amino ester) polyplex nanoparticles for delivery of self-amplifying RNA-Reference-Cited by-同舟云学术

Charge neutralized poly(β-amino ester) polyplex nanoparticles for delivery of self-amplifying RNA

Published:2024 Issue:5 Volume:6 Page:1409-1422
ISSN:2516-0230
Container-title:Nanoscale Advances
language:en
Short-container-title:Nanoscale Adv.

Author:

Dastgerdi Nazgol Karimi¹²^ORCID,Gumus Nurcan¹,Bayraktutan Hulya¹,Jackson Darryl³,Polra Krunal⁴,McKay Paul F.⁴,Atyabi Fatemeh²,Dinarvand Rassoul²⁵^ORCID,Shattock Robin J.⁴,Martinez-Pomares Luisa³^ORCID,Gurnani Pratik⁶^ORCID,Alexander Cameron¹^ORCID

Affiliation:

1. Division of Molecular Therapeutics and Formulation, School of Pharmacy, University of Nottingham, NG7 2RD, UK

2. Department of Pharmaceutical Nanotechnology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

3. School of Life Sciences, Faculty of Medicine & Health Sciences, University of Nottingham, NG7 2RD, UK

4. Department of Infectious Diseases, Section of Immunology of Infection, Imperial College London, Norfolk Place, London, W21PG, UK

5. Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 1417614315, Iran

6. UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK

Abstract

Therapeutic self-amplifying RNA (saRNA) is a promising approach for disease treatment, as it can be administered in lower doses than messenger RNA (mRNA) to achieve comparable protein production levels.

Funder

Royal Society

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NA/D3NA00794D

Reference53 articles.

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4. mRNA-based therapeutics: powerful and versatile tools to combat diseases

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