Discovery of novel phenaleno isoquinolinium-based fluorescence imaging agents for sentinel lymph node mapping

Author:

Han Ye Ri1,Lee Da-Sol2,Lee Sang Bong3,Jeon Hui-Jeon1,Lee Sijoon2ORCID,Sung Soo-Eun2,Lee Chang-Hee4,Cho Sung Jin1,Kim Kil Soo25,Kim Dong-Su6ORCID,Jeon Yong Hyun27ORCID

Affiliation:

1. New Drug Development Center Daegu-Gyeongbuk Medical Innovation Foundation Daegu 700-721, South Korea

2. Laboratory Animal Center Daegu-Gyeongbuk Medical Innovation Foundation Daegu 700-721, South Korea

3. Vaccine Commercialization Center, Gyeongbuk Institute for Bio industry, 88 Saneopdanji-gil, pungsan-eup, Andong-si, Gyeongbuk, 33618, South Korea

4. Department of Chemistry, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea

5. College of Veterinary Medicine, Kyungpook National University, Daegu 41566, South Korea

6. Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, 141 Gajeongro, Yuseong, Daejeon 31414, South Korea

7. Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, South Korea

Abstract

We reported on the development of novel fluorescent agents (called Medical Fluorophores) and their usefulness for in vivo detection in the diagnosis of sentinel lymph nodes.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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