Synthesis, ADMT prediction, and <i>in vitro</i> and <i>in silico</i> α-glucosidase inhibition evaluations of new quinoline–quinazolinone

Synthesis, ADMT prediction, and in vitro and in silico α-glucosidase inhibition evaluations of new quinoline–quinazolinone–thioacetamides

Published:2023 Issue:28 Volume:13 Page:19243-19256
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Safapoor Sajedeh¹,Halimi Mohammad²,Ghomi Minoo Khalili¹,Noori Milad³,Dastyafteh Navid³,Javanshir Shahrzad³^ORCID,Hosseini Samanesadat⁴,Mojtabavi Somayeh⁵,Faramarzi Mohammad Ali⁵^ORCID,Nasli-Esfahani Ensieh⁶,Larijani Bagher¹,Fakhrioliaei Azadeh⁷,Dekamin Mohammad G.³,Mohammadi-Khanaposhtani Maryam⁸^ORCID,Mahdavi Mohammad¹

Affiliation:

1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

2. Department of Biology, Islamic Azad University, Babol Branch, Babol, Iran

3. Pharmaceutical and Heterocyclic Chemistry Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran

4. Shahid Beheshti University of Medical Sciences, Tehran, Iran

5. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

6. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

7. Faculty of Pharmacy, Islamic Azad University, Pharmaceutical Sciences Branch, Tehran, Iran

8. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

Abstract

In this work, a new series of quinoline–quinazolinone–thioacetamide derivatives 9a–p were designed using a combination of effective pharmacophores of the potent α-glucosidase inhibitors.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA01790G

Reference25 articles.

1. Yeast α-Glucosidase Inhibition by Isoflavones from Plants of Leguminosae as an in Vitro Alternative to Acarbose

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