Hyphenation of lipophilic ruthenium(<scp>ii</scp>)-diphosphine core with 5-fluorouracil: an effective metallodrug against glioblastoma brain cancer cells-Reference-Cited by-同舟云学术

Hyphenation of lipophilic ruthenium(ii)-diphosphine core with 5-fluorouracil: an effective metallodrug against glioblastoma brain cancer cells

Published:2024 Issue:4 Volume:53 Page:1551-1567
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Saha Abhijit¹^ORCID,Mondal Indranil²,Kumari Anuj²,Sonkar Avinash Kumar¹,Mishra Ramranjan¹,Kulshreshtha Ritu²^ORCID,Patra Ashis K.¹^ORCID

Affiliation:

1. Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, Uttar Pradesh, India

2. Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India

Abstract

The anticancer antimetabolite, 5-fluorouracil (5-FU) is caged within a lipophilic Ru(ii)-diphosphine (dppe) core in [RuII(dppe)2(5-FU)]PF6 (Ru-DPPE-5FU), and its therapeutic potential towards LN229 glioblastoma cells was evaluated.

Funder

Ministry of Human Resource Development

Council of Scientific and Industrial Research, India

Indian Council of Medical Research

Science and Engineering Research Board

Department of Biotechnology, Government of West Bengal

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/DT/D3DT02941G

Reference41 articles.

1. Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?

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5. Thirty Years of the Drug Candidate NAMI‐A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective

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