Thirty Years of the Drug Candidate NAMI‐A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective-Reference-Cited by-同舟云学术

Thirty Years of the Drug Candidate NAMI‐A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective

Published:2016-09-28 Issue:12 Volume:2017 Page:1549-1560
ISSN:1434-1948
Container-title:European Journal of Inorganic Chemistry
language:en
Short-container-title:Eur. J. Inorg. Chem.

Author:

Alessio Enzo¹^ORCID

Affiliation:

1. Department of Chemical and Pharmaceutical SciencesUniversity of TriesteVia L. Giorgieri 134127TriesteItaly

Funder

Beneficentia Stiftung

University of Trieste

Publisher

Wiley

Subject

Inorganic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ejic.201600986

Reference170 articles.

1. A Phase I and Pharmacological Study with Imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a Novel Ruthenium Anticancer Agent

2. Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy

3. Contrary to what can be found in some papers the nickname NAMI is not the acronym of “New Anticancer Metastasis Inhibitor” but has a much more prosaic origin. It was created by a student as a short‐form name of the chemical formula of the complex: “NA” comes from the symbol for sodium and “MI” from the word imidazole. The corresponding imidazolium salt was simply called NAMI‐A to signify that it was an upgraded version of the prototype NAMI.

4. Na[trans-RuCl4(DMSO)Im], a metal complex of ruthenium with antimetastatic properties

5. Effects of the Ru(III) complexes [mer-RuCl3(DMSO)2Im]° and Na[trans-RuCl4(DMSO)Im] on solid mouse tumors

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