A biosensor based on multifunctional allostery for dynamic analysis of circulating tumor DNA-Reference-Cited by-同舟云学术

A biosensor based on multifunctional allostery for dynamic analysis of circulating tumor DNA

Published:2020 Issue:30 Volume:56 Page:4184-4187
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Lu Xing¹²³⁴⁵,Wang Liqian⁶⁷⁸⁹¹⁰,Chen Qingxue¹²³⁴⁵,Wang Yulan¹²³⁴⁵,Cao Zhenxiong¹²³⁴⁵,Zhou Guobao¹²³⁴⁵^ORCID,Li Lei¹²³⁴⁵

Affiliation:

1. College of Biological

2. Chemical Sciences and Engineering

3. Jiaxing University

4. Jiaxing 314001

5. China

6. State Key Laboratory of Molecular Engineering of Polymers

7. Department of Macromolecular Science

8. Fudan University

9. Shanghai 200433

10. P. R. China

Abstract

Multifunctional allosterically regulated DNA molecule beacon assay was applied to engineer a single-step, amplified and dynamic biosensor for controllable analyses of ctDNA.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC01560A

Reference18 articles.

1. Aptamers for allosteric regulation

2. Allosteric DNA nanoswitches for controlled release of a molecular cargo triggered by biological inputs

3. Control of CRISPR-Cas9 with small molecule-activated allosteric aptamer regulating sgRNAs

4. Development of small molecule biosensors by coupling the recognition of the bacterial allosteric transcription factor with isothermal strand displacement amplification

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