Control of CRISPR-Cas9 with small molecule-activated allosteric aptamer regulating sgRNAs-Reference-Cited by-同舟云学术

Control of CRISPR-Cas9 with small molecule-activated allosteric aptamer regulating sgRNAs

Published:2019 Issue:81 Volume:55 Page:12223-12226
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Lin Bingqian¹²³⁴⁵,An Yuan¹²³⁴⁵,Meng Lingyan¹²³⁴⁵,Zhang Huimin⁶⁷⁸⁹¹⁰,Song Jia⁶⁷⁸⁹¹⁰,Zhu Zhi¹²³⁴⁵,Liu Wen¹¹¹²¹³¹⁴¹⁰,Song Yanling¹²³⁴⁵^ORCID,Yang Chaoyong¹²³⁴⁵^ORCID

Affiliation:

1. MOE Key Laboratory of Spectrochemical Analysis & Instrumentation

2. Collaborative Innovation Center of Chemistry for Energy Materials

3. Key Laboratory for Chemical Biology of Fujian Province

4. State Key Laboratory of Physical Chemistry of Solid Surfaces

5. College of Chemistry and Chemical Engineering

6. Institute of Molecular Medicine

7. Renji Hospital

8. Shanghai Jiao Tong University School of Medicine

9. Shanghai

10. China

11. School of Pharmaceutical Sciences

12. Fujian Provincial Key Laboratory of Innovative Drug Target Research

13. Xiamen University

14. Xiamen

Abstract

We developed small molecule-activated allosteric aptamer regulating sgRNAs to control CRISPR-Cas9 with minimal interference to the sgRNA structure and high universality.

Funder

National Basic Research Program of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C9CC05531B

Reference25 articles.

1. A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

2. Multiplex Genome Engineering Using CRISPR/Cas Systems

3. Genome engineering using the CRISPR-Cas9 system

4. Applications of CRISPR technologies in research and beyond

5. Direct Visualization of Single-Nucleotide Variation in mtDNA Using a CRISPR/Cas9-Mediated Proximity Ligation Assay

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