Catalyst-controlled selective mono-/dialkylation of 2-aryl-4(3H)-quinazolinones-Reference-Cited by-同舟云学术

Catalyst-controlled selective mono-/dialkylation of 2-aryl-4(3H)-quinazolinones

Published:2019 Issue:14 Volume:6 Page:2348-2352
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Luo Yi¹²³⁴⁵,He Hua¹²³⁴⁵,Li Jianglian¹²³⁴⁵,Yu Xinling¹²³⁴⁵,Guan Mei⁶⁷⁸,Wu Yong¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry

2. West China School of Pharmacy

3. Sichuan University

4. Chengdu

5. P.R. China

6. West China School of Pharmacy and West China Hospital Sichuan University

7. Chengdu 610041

8. P. R. China

Abstract

Catalyst-controlled selective mono-/dialkylation of 2-aryl-4(3H)-quinazolinones with α-diazotized Meldrum's acid has been achieved successfully via a metal carbene migratory insertion process.

Funder

National Natural Science Foundation of China

Sichuan Province Youth Science and Technology Innovation Team

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/QO/C9QO00496C

Reference36 articles.

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5. Some new 2,3,6-trisubstituted quinazolinones as potent anti-inflammatory, analgesic and COX-II inhibitors

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