Construction of bridged cyclic N,O-ketal spirooxindoles through a Michael addition/N,O-ketalization sequence-Reference-Cited by-同舟云学术

Construction of bridged cyclic N,O-ketal spirooxindoles through a Michael addition/N,O-ketalization sequence

Published:2018 Issue:10 Volume:16 Page:1751-1759
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhu Yanshuo¹²³⁴⁵,Guo Jia¹²³⁴⁵,Jin Shaojing¹²³⁴⁵,Guo Jiaomei¹²³⁴⁵,Bai Xuguan¹²³⁴⁵,Wang Qilin¹²³⁴⁵^ORCID,Bu Zhanwei¹²³⁴⁵

Affiliation:

1. Institute of Functional Organic Molecular Engineering

2. College of Chemistry and Chemical Engineering

3. Henan University

4. Kaifeng 475004

5. China

Abstract

The first highly diastereoselective TfOH-catalyzed Michael addition/N,O-ketalization sequence of 3-aminooxindoles and ortho-hydroxychalcones was achieved to afford a wide range of bridged cyclic N,O-ketal spirooxindoles in 41–97% yields.

Funder

National Natural Science Foundation of China

Foundation of Henan Educational Committee

Henan University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB00306H

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