Tandem reduction and trifluoroethylation of quinolines and quinoxalines with trifluoroacetic acid and trimethylamine borane-Reference-Cited by-同舟云学术

Tandem reduction and trifluoroethylation of quinolines and quinoxalines with trifluoroacetic acid and trimethylamine borane

Published:2022 Issue:48 Volume:20 Page:9613-9617
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Li Yi-Na¹,Zhou Ming-Xi¹,Wu Jin-Bo¹,Wang Zhen¹^ORCID,Zeng Yao-Fu¹^ORCID

Affiliation:

1. School of Pharmaceutical Science, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China

Abstract

A metal-free tandem reduction and N-trifluoroethylation of quinolines and quinoxalines has been developed using trifluoroacetic acid as an inexpensive fluorinating source in the presence of Me3N–BH3.

Funder

Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01923J

Reference40 articles.

1. Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators (Part 2)

2. Contribution of Organofluorine Compounds to Pharmaceuticals