Tandem reduction and trifluoroethylation of quinolines and quinoxalines with trifluoroacetic acid and trimethylamine borane

Author:

Li Yi-Na1,Zhou Ming-Xi1,Wu Jin-Bo1,Wang Zhen1ORCID,Zeng Yao-Fu1ORCID

Affiliation:

1. School of Pharmaceutical Science, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China

Abstract

A metal-free tandem reduction and N-trifluoroethylation of quinolines and quinoxalines has been developed using trifluoroacetic acid as an inexpensive fluorinating source in the presence of Me3N–BH3.

Funder

Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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