Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition-Reference-Cited by-同舟云学术

Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition

Published:2015 Issue:1 Volume:6 Page:237-245
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Kreuzer Johannes¹²³⁴⁵,Bach Nina C.¹²³⁴⁵,Forler Daniel⁶⁷⁸,Sieber Stephan A.¹²³⁴⁵

Affiliation:

1. Center for Integrated Protein Science CIPSM

2. Institute of Advanced Studies IAS

3. Department Chemie

4. Lehrstuhl für Organische Chemie II

5. Technische Universität München

6. Bayer HealthCare Bayer Pharma AG

7. 13353 Berlin

8. Germany

Abstract

Using a chemical proteomic strategy we analyzed the targets of acivicin and provided a mechanistic explanation for its inhibition of cancer cell growth.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/SC/C4SC02339K

Reference50 articles.

1. U-42, 126, a New Antimetabolite Antibiotic: Production, Biological Activity, and Taxonomy of the Producing Microorganism

2. Acivicin in 1985

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