Affiliation:
1. Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University
of Technology, Hangzhou, 310014, Zhejiang, China
2. College of Pharmaceutical Sciences, Zhejiang University,
Hangzhou, 310058, Zhejiang, China
Abstract
Background:
Mammals are exposed to various endogenous and exogenous aldehydes,
and aldehyde dehydrogenases (ALDHs) function to metabolize these aldehydes
into acids in order to counteract aldehyde over-load. ALDHs, therefore, play important
roles in a series of physiological and pathophysiological processes. ALDHs activators and
inhibitors are not only important probes for exploring ALDHs functions, but promising
for the treatment of toxic aldehyde-related diseases.
Methods:
This review has comprehensively summarized the categories and characteristics
of 19 human ALDHs, elaborated their related biological pathways, such as alcohol metabolism,
retinoic acid (RA) production, neurotransmitter metabolism, etc. In addition, reported
ALDHs activators and inhibitors have been summarized by listing their target, inhibition
form, and clinical application.
Results:
On the one hand, summarization of the types and relative functions is useful for
further research on aldehyde metabolic pathways and related diseases. On the other hand,
a review of existing activators and inhibitors of ALDHs contributes to discovering new
leading compounds and provides new insights.
Conclusion:
In consideration of the important role ALDH plays in toxic aldehyde-related
diseases, ALDHs are promising targets for the treatment of toxic aldehyde-related diseases,
and more research efforts are required to explore their pathophysiology and to develop
new regulators.
Funder
National Natural Science Foundation of China
National Science and Technology Major Project
Zhejiang Provincial Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry