Synthesis of “neoprofen”, a rigidified analogue of ibuprofen, exemplifying synthetic methodology for altering the 3-D topology of pharmaceutical substances-Reference-Cited by-同舟云学术

Synthesis of “neoprofen”, a rigidified analogue of ibuprofen, exemplifying synthetic methodology for altering the 3-D topology of pharmaceutical substances

Published:2016 Issue:33 Volume:14 Page:7855-7858
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ramsubhag Ron R.¹²³⁴,Massaro Chelsea L.¹²³⁴,Dadich Christina M.¹²³⁴,Janeczek Andrew J.¹²³⁴,Hoang Tung T.¹²³⁴,Mazzio Elizabeth A.⁵⁶³⁴,Eyunni Suresh⁵⁶³⁴,Soliman Karam F. A.⁵⁶³⁴,Dudley Gregory B.¹²³⁴⁷

Affiliation:

1. Department of Chemistry and Biochemistry

2. Florida State University

3. Tallahassee

4. USA

5. College of Pharmacy and Pharmaceutical Sciences

6. Florida Agricultural and Mechanical University

7. C. Eugene Bennett Department of Chemistry

Abstract

The unique hydrophobic 3-D topology of the neopentylene ring fusion is explored in the context of an analogue of the non-steroidal anti-inflammatory drug, ibuprofen.

Funder

National Institute on Minority Health and Health Disparities

Division of Chemistry

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01351A

Reference13 articles.

1. Structure of illudol, a sesquiterpenoid triol from Clitocybe illudens

2. The tremulanes, a new group of sesquiterpenes from the aspen rotting fungus Phellinus tremulae