Synthesis and PTP Inhibitory Activity of Illudalic Acid and Its Methyl Ether, with Insights into Selectivity for LAR PTP over Other Tyrosine Phosphatases under Physiologically Relevant Conditions-Reference-Cited by-同舟云学术

Synthesis and PTP Inhibitory Activity of Illudalic Acid and Its Methyl Ether, with Insights into Selectivity for LAR PTP over Other Tyrosine Phosphatases under Physiologically Relevant Conditions

Published:2019-12-06 Issue:12 Volume:82 Page:3386-3393
ISSN:0163-3864
Container-title:Journal of Natural Products
language:en
Short-container-title:J. Nat. Prod.

Author:

McCullough Brandon S.¹,Batsomboon Paratchata²,Hutchinson Kacey B.¹,Dudley Gregory B.²^ORCID,Barrios Amy M.¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, United States

2. C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia 26506, United States

Funder

Division of Chemistry

West Virginia University

Teva Pharmaceutical Industries

ALSAM foundation

Eberly Foundation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.9b00663

Reference38 articles.

1. Metabolites of Clitocybe illudens. IV. Illudalic acid, a sesquiterpenoid, and illudinine, a sesquiterpenoid alkaloid

2. Discovery of novel inhibitor of human leukocyte common antigen-related phosphatase

3. The Leukocyte Common Antigen-Related Protein LAR: Candidate PTP for Inhibitory Targeting

4. Transgenic mice deficient in the LAR protein-tyrosine phosphatase exhibit profound defects in glucose homeostasis.

5. Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance

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