Perspectives on conformationally constrained peptide nucleic acid (PNA): insights into the structural design, properties and applications

Author:

Suparpprom Chaturong12ORCID,Vilaivan Tirayut12ORCID

Affiliation:

1. Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Naresuan University, Tah-Poe District, Muang, Phitsanulok 65000, Thailand

2. Organic Synthesis Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Pathumwan, Bangkok 10330, Thailand

Abstract

The performance of peptide nucleic acid (PNA) can be improved through a rational design strategy based on the incorporation of conformational constraint into the PNA backbone to pre-organize the PNA into the proper conformation.

Funder

Thailand Research Fund

University of California

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

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