l-Threonine upregulates the expression of β-defensins by activating the NF-κB signaling pathway and suppressing SIRT1 expression in porcine intestinal epithelial cells-Reference-Cited by-同舟云学术

l-Threonine upregulates the expression of β-defensins by activating the NF-κB signaling pathway and suppressing SIRT1 expression in porcine intestinal epithelial cells

Published:2021 Issue:13 Volume:12 Page:5821-5836
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Wang Chenxi¹²³⁴^ORCID,Yang Yang¹²³⁴,Gao Nan¹²³⁴,Lan Jing¹²³⁴,Dou Xiujing¹²³⁴,Li Jianping¹²³⁴,Shan Anshan¹²³⁴^ORCID

Affiliation:

1. Institute of Animal Nutrition

2. Northeast Agricultural University

3. Harbin 150030

4. People's Republic of China

Abstract

The study explores the effects of l-threonine on regulating β-defensin expression, alleviating LPS-induced intestinal mucosal barrier damage and reducing inflammatory cytokine expression in porcine intestinal epithelial cell lines (IPEC-J2).

Funder

National Natural Science Foundation of China

Earmarked Fund for China Agriculture Research System

Natural Science Foundation of Heilongjiang Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/FO/D1FO00269D

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1. Antimicrobial peptides: Promising alternatives in the post feeding antibiotic era