Affiliation:
1. Research Center of Microecological Engineering Technology, Office of Academic Research, Qiqihar Medical University, Qiqihar 161006, China
2. Basic Medical Science College, Qiqihar Medical University, Qiqihar 161006, China
3. Heilongjiang Provincial Key Laboratory of Natural Medicines for Anticancer, Qiqihar Medical University, Qiqihar 161006, China
Abstract
Pu-erh tea is recognized for its weight loss effects, but its potential association with gut microbiota and metabolites remains unclear. This research explored the alterations in gut flora and metabolite composition upon treatment with a co-fermented Pu-erh tea with an aqueous corn silk extract (CPC) in obese mice by employing integrated 16S ribosomal RNA gene sequencing and untargeted metabolomics processes. For 8 weeks, mice were fed control, high-fat, and high-fat diets which included a 46 mg/mL CPC extract. The CPC extract the alleviated high-fat diet (HFD), it stimulated systemic chronic inflammation, and it reduced the body weight, daily energy consumption, and adipose tissue weight of the mice. It also modified the gut microbiota composition and modulated the Lactobacillus, Bifidobacterium, Allobaculum, Turicibacter, and Rikenella genera. Fecal metabolomics analysis revealed that the CPC extract influenced the caffeine, cysteine, methionine, tryptophan, biotin metabolism pathways, primary bile acid, and steroid biosynthesis. This research revealed that the CPC extract could inhibit HFD-stimulated abnormal weight gain and adipose tissue accumulation in mice, and modulate mice gut microbiota composition and multiple metabolic pathways.
Funder
Fundamental Research Funds for Education Department of Heilongjiang Province of China
Qiqihar Academy of Medical Sciences Item of China
Subject
Food Science,Nutrition and Dietetics
Reference40 articles.
1. Obesity phenotypes, diabetes, and cardiovascular diseases;Piche;Circ. Res.,2020
2. Malesza, I.J., Malesza, M., Walkowiak, J., Mussin, N., Walkowiak, D., Aringazina, R., Bartkowiak-Wieczorek, J., and Madry, E. (2021). High-fat, western-style diet, systemic inflammation, and gut microbiota: A narrative review. Cells, 10.
3. Dietary lipids, gut microbiota and lipid metabolism;Schoeler;Rev. Endocr. Metab. Disord.,2019
4. Interaction of gut microbiota with bile acid metabolism and its influence on disease states;Staley;Appl. Microbiol. Biotechnol.,2017
5. Bile acid-activated receptors, intestinal microbiota, and the treatment of metabolic disorders;Fiorucci;Trends Mol. Med.,2015
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献