An engineered exosome for delivering sgRNA:Cas9 ribonucleoprotein complex and genome editing in recipient cells-Reference-Cited by-同舟云学术

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An engineered exosome for delivering sgRNA:Cas9 ribonucleoprotein complex and genome editing in recipient cells

Published:2020 Issue:10 Volume:8 Page:2966-2976
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Ye Yangyang¹²³⁴⁵,Zhang Xiang¹²³⁴⁵,Xie Fei¹²³⁴⁵,Xu Bin¹²³⁴⁵,Xie Ping¹²³⁴⁵,Yang Ting¹²³⁴⁵,Shi Qian¹²³⁴⁵,Zhang Chen-Yu¹²³⁴⁵,Zhang Yujing¹²³⁴⁵,Chen Jiangning¹²³⁴⁵,Jiang Xiaohong¹²³⁴⁵,Li Jing¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Pharmaceutical Biotechnology

2. Collaborative Innovation Centre of Chemistry for Life Sciences

3. Jiangsu Engineering Research Centre for MicroRNA Biology and Biotechnology

4. NJU Advanced Institute for Life Sciences (NAILS)

5. School of Life Sciences

Abstract

CRISPR-Cas9 components delivered by engineered exosomes achieve genome editing in recipient cells.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/BM/D0BM00427H

Reference39 articles.

1. Therapeutic genome editing: prospects and challenges

2. Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin

3. Intervening Sequences of Regularly Spaced Prokaryotic Repeats Derive from Foreign Genetic Elements

4. CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies

5. A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

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