Molecular mechanism of HIV-1 TAT peptide and its conjugated gold nanoparticles translocating across lipid membranes
Author:
Affiliation:
1. School of Chemistry and Chemical Engineering
2. Guangdong Provincial Key Lab for Green Chemical Product Technology
3. South China University of Technology
4. Guangzhou
5. P. R. China
Abstract
It is demonstrated that the translocation of TAT peptides and TAT–AuNP complexes across lipid membranes is related to the peptide concentration and the number of grafted TAT peptides on the particle surface, respectively, which is mainly driven by electrostatic interactions.
Funder
National Natural Science Foundation of China
China Postdoctoral Science Foundation
Publisher
Royal Society of Chemistry (RSC)
Subject
Physical and Theoretical Chemistry,General Physics and Astronomy
Link
http://pubs.rsc.org/en/content/articlepdf/2019/CP/C9CP01543D
Reference70 articles.
1. Cell-penetrating peptides: mechanism and kinetics of cargo delivery
2. Cell‐penetrating peptides: 20 years later, where do we stand?
3. Cell-Penetrating Peptides: Design, Synthesis, and Applications
4. Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein
5. A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus
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