A linear hydroxymethyl tetramate undergoes an acetylation–elimination process for exocyclic methylene formation in the biosynthetic pathway of pyrroindomycins-Reference-Cited by-同舟云学术

A linear hydroxymethyl tetramate undergoes an acetylation–elimination process for exocyclic methylene formation in the biosynthetic pathway of pyrroindomycins

Published:2017 Issue:1 Volume:15 Page:88-91
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zheng Qingfei¹²³⁴⁵^ORCID,Wu Zhuhua¹²³⁴⁵,Sun Peng¹²³⁴⁵,Chen Dandan¹²³⁴⁵,Tian Zhenhua¹²³⁴⁵,Liu Wen¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Bioorganic and Natural Products Chemistry

2. Shanghai Institute of Organic Chemistry

3. Chinese Academy of Sciences

4. Shanghai 200032

5. China

Abstract

The exocyclic methylene formation involved in pyrroindomycin biosynthesis is mediated by an enzymatic acetylation–elimination process.

Funder

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C6OB02567F

Reference17 articles.

1. Recent advances in the field of bioactive tetronates

2. Spirotetronate Polyketides as Leads in Drug Discovery

3. Synthesis of Spirotetramates via a Diels−Alder Approach

4. Pyrroindomycins, novel antibiotics produced by Streptomyces rugosporus LL-42D005. II. Biological activities.

5. Pyrroindomycins, novel antibiotics produced by Streptomyces rugosporus sp. LL-42D005. I. Isolation and structure determination.

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