Affiliation:
1. Department of Anatomy and Physiology, Kansas State University, 1620 Denison Avenue, Manhattan, Kansas, USA
Abstract
A cyclic peptide targeted to the immune checkpoint protein CTLA4 is designed using a hierarchy of computational methods, demonstrated to bind by a physical measurement, and shown to inhibit tumor growth in cell culture and in mice.
Funder
National Science Foundation
National Cancer Institute
Johnson Cancer Research Center, Kansas State University
College of Veterinary Medicine, Kansas State University
National Heart, Lung, and Blood Institute
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献