Brønsted acid-catalyzed cascade cyclization: an efficient strategy for divergent synthesis of cyclohepta[b]indole derivatives

Author:

Chen Shaomin1,Chen Zhiyan1,Zhang Tianjian1,Zhao Bo1,You Bo1ORCID,Li Minghao1ORCID,Gu Yanlong123ORCID

Affiliation:

1. Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, 430074 Wuhan, China

2. School of Chemistry and Chemical Engineering, The Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, Shihezi University, Shihezi City 832004, China

3. State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, 730000 Lanzhou, China

Abstract

An efficient acid-catalyzed three-component cascade strategy by employing 3,3′-bis(indolyl)methanes (BIMs) as masked 1,4-nucleophiles was established for synthesizing cyclohepta[b]indoles under mild and eco-friendly conditions.

Funder

Fundamental Research Funds for the Central Universities

Henan University of Science and Technology

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

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