The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD+) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition
Author:
Affiliation:
1. Lilly Biotechnology Center San Diego, 10300 Campus Point Drive, Suite 200, San Diego, California 92121, United States
2. Lilly Corporate Center, 355 East Merrill Street, Indianapolis, Indiana, 46285, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm301431y
Reference39 articles.
1. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
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3. Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase
4. Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway
5. Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration
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