Effects of side chains on DNA binding, cell permeability, nuclear localization and cytotoxicity of 4-aminonaphthalimides-Reference-Cited by-同舟云学术

Effects of side chains on DNA binding, cell permeability, nuclear localization and cytotoxicity of 4-aminonaphthalimides

Published:2014 Issue:45 Volume:12 Page:9207-9215
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhou Jin¹²³⁴⁵,Chang Ang¹²³⁴⁵,Wang Linlin¹²³⁴⁵,Liu Ying¹²³⁴⁵,Liu Xiangjun¹²³⁴⁵,Shangguan Dihua¹²³⁴⁵

Affiliation:

1. Beijing National Laboratory for Molecular Sciences

2. Key Laboratory of Analytical Chemistry for Living Biosystems

3. Institute of Chemistry

4. Chinese Academy of Sciences

5. Beijing, 100190, China

Abstract

The guanidinoethyl group increases DNA binding, and decreases the cell permeability and cytotoxity; the dimethylaminopropyl group enhances the cell permeability and cytotoxity.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB01274G

Reference54 articles.

1. Stains, labels and detection strategies for nucleic acids assays

2. Advances in the molecular design of potential anticancer agents via targeting of human telomeric DNA

3. DNA as a target for anticancer compounds: methods to determine the mode of binding and the mechanism of action

4. DNA-binding drugs caught in action: the latest 3D pictures of drug-DNA complexes

5. Dimeric 1,3-Phenylene-bis(piperazinyl benzimidazole)s: Synthesis and Structure–Activity Investigations on their Binding with Human Telomeric G-Quadruplex DNA and Telomerase Inhibition Properties

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