Rational design, synthesis and molecular modeling studies of novel anti-oncological alkaloids against melanoma-Reference-Cited by-同舟云学术

Rational design, synthesis and molecular modeling studies of novel anti-oncological alkaloids against melanoma

Published:2015 Issue:23 Volume:13 Page:6619-6633
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Girgis Adel S.¹²³⁴,Panda Siva S.⁵⁶⁷⁸⁹,Srour Aladdin M.¹⁰²³⁴,Farag Hanaa¹²³⁴,Ismail Nasser S. M.¹¹¹²¹³¹⁴⁴,Elgendy Mohamed¹⁵¹⁶¹⁷¹⁸,Abdel-Aziz Amal K.¹⁹¹²¹³¹⁴⁴,Katritzky Alan R.⁵⁶⁷⁸⁹

Affiliation:

1. Pesticide Chemistry Department

2. National Research Centre

3. Dokki

4. Egypt

5. Center for Heterocyclic Compounds

6. Department of Chemistry

7. University of Florida

8. Gainesville

9. USA

10. Therapeutical Chemistry Department

11. Pharmaceutical Chemistry Department

12. Faculty of Pharmacy

13. Ain Shams University

14. Cairo

15. Department of Experimental Oncology at the IFOM-IEO Campus

16. European Institute of Oncology

17. 20139 Milan

18. Italy

19. Pharmacology and Toxicology Department

Abstract

Anti-oncological active spiro-alkaloids were synthesized exhibiting promising antitumor properties against melanoma cell lines. Molecular modeling studies describe the observed properties.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00410A

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