Catalyst-free, direct electrochemical synthesis of annulated medium-sized lactams through C

Catalyst-free, direct electrochemical synthesis of annulated medium-sized lactams through C–C bond cleavage

Published:2020 Issue:4 Volume:22 Page:1099-1104
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Xu Zhongnan¹²³⁴⁵,Huang Zhixing¹²³⁴⁵,Li Yueheng¹²³⁴⁵,Kuniyil Rositha⁶⁷⁸⁹,Zhang Chao¹²³⁴⁵,Ackermann Lutz⁶⁷⁸⁹^ORCID,Ruan Zhixiong¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease

2. School of Pharmaceutical Sciences & the Fifth Affiliated Hospital

3. Guangzhou Medical University

4. Guangzhou

5. P.R. China

6. Institut für Organische und Biomolekulare Chemie

7. Georg-August-Universität Göttingen

8. 37077 Göttingen

9. Germany

Abstract

Expanding ring under green electricity: The electrosynthetic approach enabled atom-economical synthesis of challenging medium-sized lactams through a unique remote amidyl migration under exceedingly mild, transition metal- and oxidant-free conditions.

Funder

National Natural Science Foundation of China

Guangzhou Municipal Science and Technology Project

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/GC/C9GC03901E

Reference87 articles.

1. Medium ring nitrogen heterocyles