Design, Synthesis, and Characterization of a Potent, Nonpeptide, Cell-Permeable, Bivalent Smac Mimetic That Concurrently Targets Both the BIR2 and BIR3 Domains in XIAP-Reference-Cited by-同舟云学术

Design, Synthesis, and Characterization of a Potent, Nonpeptide, Cell-Permeable, Bivalent Smac Mimetic That Concurrently Targets Both the BIR2 and BIR3 Domains in XIAP

Published:2007-11-14 Issue:49 Volume:129 Page:15279-15294
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Sun Haiying¹,Nikolovska-Coleska Zaneta¹,Lu Jianfeng¹,Meagher Jennifer L.¹,Yang Chao-Yie¹,Qiu Su¹,Tomita York¹,Ueda Yumi¹,Jiang Sheng¹,Krajewski Krzysztof¹,Roller Peter P.¹,Stuckey Jeanne A.¹,Wang Shaomeng¹

Affiliation:

1. Contribution from Departments of Internal Medicine, Pharmacology and Medicinal Chemistry and Comprehensive Cancer Center, Life Sciences Institute, and Biological Chemistry, Biophysics Research Division, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, Lombardi Cancer Center, Georgetown University Medical Center, Washington DC 20007, and Laboratory of Medicinal Chemistry, National Cancer InstituteFrederick, NIH, Frederick, Maryland 21702

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja074725f

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1. Cancer genetics

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3. IAP proteins: blocking the road to death's door

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