Nanozyme-enhanced ferroptosis for cancer treatment

Author:

Ming Yue1ORCID,Huang Mingshu1ORCID,Huang Yisheng1ORCID,Liu Danqing23,Sun Min234ORCID,Jia Bo1ORCID,Du Jianzhong234ORCID

Affiliation:

1. Department of Oral Surgery, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China

2. Department of Gynaecology and Obstetrics, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China

3. Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China

4. Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University, 4800 Caoan Road, Shanghai, 201804, China

Abstract

Nanozymes could mimic the catalytic activity of natural enzymes, then stimulate the Fenton reaction for reactive oxygen species overproduction and lipid peroxidation, ultimately induce ferroptosis to exert anticancer effects.

Funder

Science and Technology Commission of Shanghai Municipality

Science and Technology Planning Project of Guangdong Province

National Key Research and Development Program of China

Shanghai Municipal Education Commission

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Shanghai Rising-Star Program

Guangzhou Municipal Science and Technology Project

Publisher

Royal Society of Chemistry (RSC)

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