Strategic design and development of a siderophore mimic: pioneering anticancer therapy <i>via</i> ROS generation and ferroptosis-Reference-Cited by-同舟云学术

Strategic design and development of a siderophore mimic: pioneering anticancer therapy via ROS generation and ferroptosis

Published:2024 Issue:29 Volume:53 Page:12119-12127
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Panwar Abhishek¹,Lye Anushree²,Musib Dulal¹,Upadhyay Aarti³,Karankumar Irungbam¹,Devi Paonam Bebika¹,Pal Maynak¹,Maity Biswanath²⁴,Roy Mithun¹⁵^ORCID

Affiliation:

1. Department of Chemistry, National Institute of Technology Manipur, Langol, Imphal West, 795004, Manipur, India

2. Department of Systems Biology, Center of Biomedical Research (CBMR), Raebareli Road, Lucknow 226014, Uttar Pradesh, India

3. Department of Inorganic and Physical Chemistry, Indian Institute of Science Bangalore, Bangalore-50012, Karnataka, India

4. Department of Biological Sciences, Bose Institute Unified Academic Campus, EN80, Sector V, Bidhan Nagar, Kolkata - 700091, West Bengal, India

5. Department of Chemistry, National Institute of Technology Agartala, Jirania, West Tripura, Agartala, 799046, India

Abstract

The article reports a remarkable anticancer activity through iron(iii) chelation and ferroptosis by a newly developed catecholate-based siderophore mimic.

Funder

Board of Research in Nuclear Sciences

Science and Engineering Research Board

Indian Council of Medical Research

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/DT/D4DT01461H

Reference54 articles.

1. Iron and cancer: more ore to be mined

2. Iron metabolism: State of the art in hypoxic cancer cell biology

3. Iron imbalance in cancer: Intersection of deficiency and overload

4. Iron and Cancer Risk—A Systematic Review and Meta-analysis of the Epidemiological Evidence

5. Iron: The cancer connection