A novel strategy for rhodamine B-based fluorescent probes with a selective glutathione response for bioimaging in living cells

Author:

Li Zhipeng12345,Xiong Wei678910,He Xiaojun12345,Qi Xiaoliang12345,Ding Feng111251310,Shen Jianliang12345ORCID

Affiliation:

1. State Key Laboratory of Ophthalmology

2. Optometry and Vision Science

3. School of Ophthalmology and Optometry

4. School of Biomedical Engineering

5. Wenzhou Medical University

6. Department of Urology

7. Xiangya Hospital

8. Central South University

9. Changsha 410008

10. China

11. Department of Microbiology & Immunology

12. School of Basic Medical Sciences

13. Wenzhou 325035

Abstract

The aim of this study was to overcome the reported shortcomings of the glutathione (GSH) detection of rhodamine-based fluorescent probes, such as poor selectivity to thiol groups and reversible unstable covalent binding with the thiol groups.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Wenzhou Medical University

Wenzhou Institute of Biomaterials and Engineering

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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