Accelerated DNA tetrahedron-based molecular beacon for efficient microRNA imaging in living cells

Author:

Xing Chao12345ORCID,Chen Ziyi67895,Lin Yuhong67895,Wang Min67895,Xu Xin67895,Dai Junduan67895,Wang Jun12345,Lu Chunhua67895ORCID

Affiliation:

1. Fujian Key Laboratory of Functional Marine Sensing Materials

2. Center for Advanced Marine Materials and Smart Sensors

3. Minjiang University

4. Fuzhou 350108

5. P. R. China

6. MOE Key Laboratory for Analytical Science of Food Safety and Biology

7. Fujian College of Chemistry

8. Fuzhou University

9. Fuzhou 350116

Abstract

Herein, we develop an accelerated DNA tetrahedron based molecular beacon for efficient detection and imaging of miRNA in living cells. Our study provides an improved strategy for fluorescence amplified RNA imaging in early clinical diagnosis.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Fujian Province

National Key Research and Development Program of China

Science and Technology Planning Project of Fuzhou

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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