Tuning activation and self-immolative properties of the bioorthogonal alkene–azide click-and-release strategy-Reference-Cited by-同舟云学术

Tuning activation and self-immolative properties of the bioorthogonal alkene–azide click-and-release strategy

Published:2020 Issue:25 Volume:18 Page:4754-4762
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Fairhall Jessica M.¹²³⁴,Murayasu Madoka¹²³⁴,Dadhwal Sumit¹²³⁴,Hook Sarah¹²³⁴,Gamble Allan B.¹²³⁴^ORCID

Affiliation:

1. School of Pharmacy

2. University of Otago

3. Dunedin

4. New Zealand

Abstract

Combinations of aryl azides and trans-cyclooctenes have been studied in a bioorthogonal click-and-release strategy, with two reaction pairings rapidly releasing phenol at micromolar concentrations.

Funder

Health Research Council of New Zealand

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB00936A

Reference42 articles.

1. Development and application of bond cleavage reactions in bioorthogonal chemistry

2. Inverse electron demand Diels–Alder reactions in chemical biology

3. Dissociative Bioorthogonal Reactions

4. The Emerging Role of Tetrazines in Drug‐Activation Chemistries

5. Bioorthogonal Decaging Reactions for Targeted Drug Activation

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