Replacing DMF in solid-phase peptide synthesis: varying the composition of green binary solvent mixtures as a tool to mitigate common side-reactions
Author:
Affiliation:
1. Bachem AG
2. 4416 Bubendorf
3. Switzerland
4. Novo Nordisk A/S
5. CMC API Development
6. DK-2880 Bagsværd
7. Denmark
8. School of Chemistry and Physics
9. University of KwaZulu-Natal
10. Westville
11. South Africa
12. CIBER-BBN
Abstract
The composition of green binary solvent mixtures is used as a tool to mitigate side-reactions in SPPS.
Funder
Novo Nordisk
Publisher
Royal Society of Chemistry (RSC)
Subject
Pollution,Environmental Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/GC/D1GC00604E
Reference49 articles.
1. Manufacturing peptides as active pharmaceutical ingredients
2. From Production of Peptides in Milligram Amounts for Research to Multi-Tons Quantities for Drugs of the Future
3. Related impurities in peptide medicines
4. Y. Yang , Side Reactions in Peptide Synthesis , Elsevier , 2015
5. Thirteen decades of peptide synthesis: key developments in solid phase peptide synthesis and amide bond formation utilized in peptide ligation
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