Replacing DMF in solid-phase peptide synthesis: varying the composition of green binary solvent mixtures as a tool to mitigate common side-reactions-Reference-Cited by-同舟云学术

Replacing DMF in solid-phase peptide synthesis: varying the composition of green binary solvent mixtures as a tool to mitigate common side-reactions

Published:2021 Issue:9 Volume:23 Page:3312-3321
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Jadhav Sandip¹²³^ORCID,Martin Vincent⁴⁵⁶⁷^ORCID,Egelund Peter H. G.⁴⁵⁶⁷,Johansson Castro Henrik⁴⁵⁶⁷^ORCID,Krüger Tobias¹²³,Richner Franziska¹²³,Thordal Le Quement Sebastian⁴⁵⁶⁷,Albericio Fernando⁸⁹¹⁰¹¹¹²^ORCID,Dettner Frank¹²³,Lechner Carolin¹²³,Schönleber Ralph¹²³^ORCID,Pedersen Daniel Sejer⁴⁵⁶⁷^ORCID

Affiliation:

1. Bachem AG

2. 4416 Bubendorf

3. Switzerland

4. Novo Nordisk A/S

5. CMC API Development

6. DK-2880 Bagsværd

7. Denmark

8. School of Chemistry and Physics

9. University of KwaZulu-Natal

10. Westville

11. South Africa

12. CIBER-BBN

Abstract

The composition of green binary solvent mixtures is used as a tool to mitigate side-reactions in SPPS.

Funder

Novo Nordisk

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/GC/D1GC00604E

Reference49 articles.

1. Manufacturing peptides as active pharmaceutical ingredients

2. From Production of Peptides in Milligram Amounts for Research to Multi-Tons Quantities for Drugs of the Future

4. Y. Yang , Side Reactions in Peptide Synthesis , Elsevier , 2015

5. Thirteen decades of peptide synthesis: key developments in solid phase peptide synthesis and amide bond formation utilized in peptide ligation

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