Effects of the ApoE genotype on cognitive function in aging mice fed with a high-fat diet and the protective potential of n-3 polyunsaturated fatty acids-Reference-Cited by-同舟云学术

Effects of the ApoE genotype on cognitive function in aging mice fed with a high-fat diet and the protective potential of n-3 polyunsaturated fatty acids

Published:2024 Issue:4 Volume:15 Page:2249-2264
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Zhang Xin¹,Xie Tianzhi¹,Zhou Shuang¹,Yuan Yingxuan¹,Chen Weixuan¹^ORCID,Zheng Jie²,Liu Xuebo¹^ORCID,Yuan Tian³⁴,Lu Yanhui²,Liu Zhigang¹³⁵^ORCID

Affiliation:

1. Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China

2. School of Nursing, Peking University, 100191, Beijing, China

3. Northwest A&F University Shenzhen Research Institute, Shenzhen, Guangdong, 518000, China

4. Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, China

5. Dongguan Chuangwei Precision Nutrition and Health Innovation Center, Dongguan, Guangdong, 523170, China

Abstract

The ApoE4 allele is the strongest genetic determinant for AD, while obesity is a strong environmental risk for AD. Importantly, n-3 PUFAs may serve as a strategic nutritional intervention for brain health, especially for ApoE4 carriers.

Funder

National Natural Science Foundation of China

Science and Technology Planning Project of Shenzhen Municipality

Shenzhen Fundamental Research Program

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/FO/D3FO03965J

Reference59 articles.

1. Alzheimer's disease

2. Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

3. ApoE-Dependent Protective Effects of Sesamol on High-Fat Diet-Induced Behavioral Disorders: Regulation of the Microbiome-Gut–Brain Axis

4. Effects of APOE Genotype and Western Diet on Metabolic Phenotypes in Female Mice

5. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

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