d-/l-Isothymidine incorporation in the core sequence of aptamer BC15 enhanced its binding affinity to the hnRNP A1 protein-Reference-Cited by-同舟云学术

d-/l-Isothymidine incorporation in the core sequence of aptamer BC15 enhanced its binding affinity to the hnRNP A1 protein

Published:2018 Issue:40 Volume:16 Page:7488-7497
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Li Liyu¹²³⁴⁵^ORCID,Yang Xiantao¹²³⁴⁵^ORCID,Li Kunfeng¹²³⁴⁵,Zhang Guangpu¹²³⁴⁵,Ma Yuan¹²³⁴⁵^ORCID,Cai Baobin¹²³⁴⁵,Li Shaohua⁶⁷⁸⁵,Ding Hongmei⁶⁷⁸⁵,Deng Jiali¹²³⁴⁵,Nan Xiyan¹²³⁴⁵,Sun Jing¹²³⁴⁵,Wu Yun¹²³⁴⁵,Shao Ningsheng⁶⁷⁸⁵,Zhang Lihe¹²³⁴⁵,Yang Zhenjun¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Natural and Biomimetic Drugs

2. School of Pharmaceutical Sciences

3. Peking University

4. Beijing 100191

5. China

6. Department of Biochemistry and Molecular Biology

7. Beijing Institute of Basic Medical Sciences

8. Beijing

Abstract

Truncation of BC15 and d-/l-isothymidine modification of its core sequence greatly enhanced the binding affinity and selectivity to the hnRNP A1 protein.

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB01454J

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