Aptamers as therapeutics
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd3141.pdf
Reference170 articles.
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3. Morozova, N. et al. Protein–RNA interactions: exploring binding patterns with a three-dimensional superposition analysis of high resolution structures. Bioinformatics 22, 2746–2752 (2006).
4. Nagai, K. RNA–protein complexes. Curr. Opin. Struct. Biol. 6, 53–61 (1996).
5. Ellington, A. D. & Szostak, J. W. In vitro selection of RNA molecules that bind specific ligands. Nature 346, 818–822 (1990). One of the first two publications of the SELEX technique. Aptamers were selected from a random-sequence RNA library against dyes in a proof-of-principle experiment.
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