Metabolic alterations in dairy cattle with lameness revealed by untargeted metabolomics of dried milk spots using direct infusion-tandem mass spectrometry and the triangulation of multiple machine learning models

Author:

He Wenshi1ORCID,Cardoso Ana S.2,Hyde Robert M.2,Green Martin J.2ORCID,Scurr David J.1,Griffiths Rian L.1ORCID,Randall Laura V.2ORCID,Kim Dong-Hyun1ORCID

Affiliation:

1. Centre for Analytical Bioscience, Advanced Materials & Healthcare Technologies Division, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK

2. School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Leicestershire, LE12 5RD, UK

Abstract

Metabolic alteration and metabolite indicators associated with cattle lameness were discovered by untargeted metabolomics analysis of dried milk spots using direct infusion mass spectrometry and triangulation of statistical models.

Funder

Academy of Medical Sciences

University of Nottingham

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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