Structure-guided evolution of a ketoreductase for efficient and stereoselective bioreduction of bulky α-amino β-keto esters-Reference-Cited by-同舟云学术

Structure-guided evolution of a ketoreductase for efficient and stereoselective bioreduction of bulky α-amino β-keto esters

Published:2021 Issue:20 Volume:11 Page:6755-6769
ISSN:2044-4753
Container-title:Catalysis Science & Technology
language:en
Short-container-title:Catal. Sci. Technol.

Author:

Tang Jiawei¹^ORCID,Chen Liuqing²^ORCID,Zhang Luwen³,Ni Guowei³,Yu Jun³,Wang Hongyi³,Zhang Fuli³,Yuan Shuguang²,Feng Meiqing¹,Chen Shaoxin³^ORCID

Affiliation:

1. Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai 201203, P. R. China

2. Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P. R. China

3. Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai 201203, P. R. China

Abstract

Chiral vicinal amino alcohols were generated with excellent stereoselectivity and high conversion from bulky α-amino β-keto esters by an engineered ketoreductase called M30.

Funder

Program of Shanghai Academic Research Leader

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CY/D1CY01032H

Reference63 articles.

1. The Synthesis of Vicinal Amino Alcohols

2. Multi-Enzymatic Synthesis of Optically Pure β-Hydroxy α-Amino Acids

3. Industrial Methods for the Production of Optically Active Intermediates