Development of an Efficient and Scalable Asymmetric Synthesis of Eliglustat via Ruthenium(II)-Catalyzed Asymmetric Transfer Hydrogenation-Reference-Cited by-同舟云学术

Development of an Efficient and Scalable Asymmetric Synthesis of Eliglustat via Ruthenium(II)-Catalyzed Asymmetric Transfer Hydrogenation

Published:2019-05-23 Issue:6 Volume:23 Page:1204-1212
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Sun Guodong¹²^ORCID,Jian Weilin³,Luo Zhonghua³,Sun Tengfei³,Li Chao³,Zhang Jiancun¹,Wang Zhongqing³⁴^ORCID

Affiliation:

1. Guangzhou Institutes of Biomedicine and Heath, Chinese Academy of Sciences, 190 Kaiyuan Road, Guangzhou 510530, P.R. China

2. University of Chinese Academy of Sciences, No. 19 Yuquan Road, Beijing 100049, P.R. China

3. HEC Research and Development Center, HEC Pharm Group, Dongguan 523871, P.R. China

4. Anti-infection Innovation Department, New Drug Research Institute, HEC Pharma Group, Dong Guan 523871, P.R. China

Funder

Anti-infective Drug National Key Laboratory

Key Science & Technology Brainstorm Project of Dongguan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00138

Reference28 articles.

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2. Eliglustat tartrate for the treatment of adults with type 1 Gaucher disease

3. Eliglustat: First Global Approval

4. aHirth, B. H.; Siegel, C. Synthesis of UDP-glucose: N-Acylsphingosineglucosyltransferase inhibitors. Patent Appl. WO03008399 A1, 2003.

5. bWang, B. N-(1-hydroxy-3-(pyrrolidinyl)propan-2-yl)pyrrolidine-3-carboxamide derivatives as glucosylceramide synthase inhibitors. Patent Appl. WO2015065937 A1, 2015.

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