Oxidative steps during the biosynthesis of squalestatin S1
Author:
Affiliation:
1. Institute for Organic Chemistry
2. BMWZ
3. Leibniz Universität Hannover
4. 30167 Hannover
5. Germany
Abstract
Two enzymes of previously unknown function encoded by the squalestatin biosynthetic gene cluster from the fungus Phoma MF5453 catalyse a remarkable series of six consecutive oxidations to form the 4,8-dioxa-bicyclo[3.2.1]octane core of the squalestatins.
Funder
Deutsche Forschungsgemeinschaft
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/SC/C8SC02615G
Reference20 articles.
1. Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase.
2. The squalestatings, novel inhibitors of squalene synthase produced by a species of Phoma. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.
3. The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. III. Biosynthesis.
4. Identification of genes encoding squalestatin S1 biosynthesis and in vitro production of new squalestatin analogues
5. Identification and Heterologous Production of a Benzoyl-Primed Tricarboxylic Acid Polyketide Intermediate from the Zaragozic Acid A Biosynthetic Pathway
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