Identification of genes encoding squalestatin S1 biosynthesis and in vitro production of new squalestatin analogues-Reference-Cited by-同舟云学术

Identification of genes encoding squalestatin S1 biosynthesis and in vitro production of new squalestatin analogues

Published:2016 Issue:41 Volume:52 Page:6777-6780
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Bonsch B.¹²³⁴,Belt V.¹²³⁴,Bartel C.¹²³⁴,Duensing N.¹²³⁴,Koziol M.⁵⁶⁷,Lazarus C. M.⁵⁶⁷,Bailey A. M.⁵⁶⁷,Simpson T. J.⁸⁹¹⁰⁷,Cox R. J.¹²³⁴⁸

Affiliation:

1. Institut für Organische Chemie

2. Leibniz Universität Hannover

3. 30167 Hannover

4. Germany

5. School of Biological Sciences

6. Bristol BS8 1TQ

7. UK

8. School of Chemistry

9. University of Bristol

10. Bristol

Abstract

Biosynthetic gene clusters encoding the production of squalestatin S1 have been discovered and exploited to produce new analogs.

Funder

Engineering and Physical Sciences Research Council

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CC/C6CC02130A

Reference26 articles.

1. The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. II. Structure elucidation.

2. Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase.

3. Competitive inhibition of squalene synthetase by squalestatin 1.

4. The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. IV. Preparation of fluorinated squalestatins by directed biosynthesis.

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