Design and synthesis of herboxidiene derivatives that potently inhibit in vitro splicing-Reference-Cited by-同舟云学术

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Design and synthesis of herboxidiene derivatives that potently inhibit in vitro splicing

Published:2021 Issue:6 Volume:19 Page:1365-1377
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ghosh Arun K.¹²³⁴^ORCID,Allu Srinivasa Rao¹²³⁴,Reddy Guddeti Chandrashekar¹²³⁴,Lopez Adriana Gamboa⁵⁶⁷⁴,Mendez Patricia⁵⁶⁷⁴,Jurica Melissa S.⁵⁶⁷⁴

Affiliation:

1. Department of Chemistry and Department of Medicinal Chemistry and Molecular Pharmacology

2. Purdue University

3. West Lafayette

4. USA

5. Department of Molecular Cell and Developmental Biology and Center for Molecular Biology of RNA

6. University of California

7. Santa Cruz

Abstract

Enantioselective syntheses of C-6 modified derivatives of herboxidiene and their biological evaluation in splicing inhibitory assay.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D0OB02532A

Reference47 articles.

1. SPLICING OF MESSENGER RNA PRECURSORS

2. Alternative isoform regulation in human tissue transcriptomes

3. RNA splicing factors as oncoproteins and tumour suppressors

4. The pathogenicity of splicing defects: mechanistic insights into pre‐ mRNA processing inform novel therapeutic approaches

5. Pre-mRNA Splicing

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4. Herboxidiene Features That Mediate Conformation-Dependent SF3B1 Interactions to Inhibit Splicing;ACS Chemical Biology;2021-02-22

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